| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers
(credit only) |
| Jon Huertas | Javier Esposito |
| Seamus Dever | Kevin Ryan |
| Tamala Jones | Lanie Parish |
| Molly C. Quinn | Alexis Castle
(as Molly Quinn) (credit only) |
| Penny Johnson Jerald | Captain Victoria Gates |
| Andrew J. West | Keith |
| C. Thomas Howell | John Campbell |
| Daniel Roebuck | Joe Silva |
| Nick Thurston | Buck Cooper /
Hank Rodgers |
| Chris Coy | Zeke |
| Amir Talai | Sam Spear |
| Kristen Miller | Caroline |
| Max Arciniega | Billy Bash |
| Brian Maillard | Joel Mitas |
| Sarah Scott | Butterfly |
| Hunter Jackson | James Swan |
| Lydia Hull | Front Desk Clerk |
| Brian Kong | Uniform Officer |
| Aussie Guevara | Keith's Girl
(uncredited) |
| Justin Sandler | New Guitarist
(uncredited) |
| L.T. Tolliver | LT
(uncredited) |