| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Ruben Santiago-Hudson | Captain Roy Montgomery |
| Molly C. Quinn | Alexis Castle |
| Jon Huertas | Javier Esposito |
| Tamala Jones | Lanie Parish |
| Seamus Dever | Kevin Ryan |
| Max Martini | Hal Lockwood |
| Scott Paulin | Jim Beckett |
| Brian Goodman | Gary McCallister |
| Judith Scott | Evelyn Montgomery |
| Matt McTighe | Chuck Ryker |
| George Gerdes | Mike Yanavich |
| Malcolm Foster Smith | Dwight Haskell |
| Danièle Watts | Rebecca Montgomery
(as Daniele Watts) |
| LaNiesha Irvin | Mary Montgomery
(as LaNiesha-Jopré Irvin) |
| Sean Blodgett | Avery Zussman |
| Priscilla Garita | Bridge Officer |
| Jeffrey Kennedy | Young Gary McCallister
(as Jeffrey S. Kennedy) |
| Kane Richard Blust | Prisoner
(uncredited) |
| Derri Dias | Funeral Family Member
(uncredited) |
| Chris Gann | Fake Cop
(uncredited) |
| Waymond Lee | Prison Inmate
(uncredited) |
| Naomi Peters | Woman in Hallway
(uncredited) |