| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Ruben Santiago-Hudson | Captain Roy Montgomery |
| Molly C. Quinn | Alexis Castle
(as Molly Quinn) |
| Jon Huertas | Javier Esposito |
| Tamala Jones | Lanie Parish
(credit only) |
| Seamus Dever | Kevin Ryan |
| Michael McKean | Victor Baron |
| Arye Gross | M.E. Sidney Perlmutter |
| Sasha Roiz | Bobby Stark |
| Amanda Schull | Joy Jones |
| Jonathan Slavin | Justin Hankel |
| Bellamy Young | Candace Ford |
| Ken Baumann | Ashley |
| Judith Scott | Evelyn Montgomery |
| Terrell Clayton | Dax Lattimer |
| William Francis McGuire | Dan Middleberry |
| Teri Polo | Kayla Baron |
| Krystal Joy Brown | Sascha |
| Stephanie Lynn | Amber Middleberry |
| Rosero McCoy | Felix |
| Nan McNamara | Stage Mother |
| Rose Bryant | Ms. Virginia
(uncredited) |
| Marcy McCusker | Dancer
(uncredited) |