| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Ruben Santiago-Hudson | Captain Roy Montgomery |
| Molly C. Quinn | Alexis Castle
(as Molly Quinn) |
| Jon Huertas | Javier Esposito |
| Tamala Jones | Lanie Parish
(credit only) |
| Seamus Dever | Kevin Ryan |
| Anne Ramsay | Bree Busch |
| Arye Gross | M.E. Sidney Perlmutter |
| Robert Curtis Brown | Ian Busch |
| Erin Foster | Sky Blue |
| Clayton Rohner | John McGinnis |
| Jesse Head | Zack Metzger
(as Jesse John Head) |
| Bernardo De Paula | Franco Marquez
(as Bernardo de Paula) |
| Brianna Haynes | Hayley Blue |
| Rashawn Underdue | Tony |
| Dominic Prietto | Hot Guy in Hayley Blue Music Video
(uncredited) |
| Erik Saari | Creepy Guy on Bus
(uncredited) |