| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Ruben Santiago-Hudson | Captain Roy Montgomery
(credit only) |
| Molly C. Quinn | Alexis Castle
(as Molly Quinn) |
| Jon Huertas | Javier Esposito |
| Tamala Jones | Lanie Parish |
| Seamus Dever | Kevin Ryan |
| Jeffrey Pierce | Wyatt Monroe |
| Matt Barr | Travis McBoyd |
| Torrey DeVitto | Sierra Goodwin |
| Shanna Collins | Rina |
| Julian Sands | Teddy Farrow |
| Jon Fleming | Will James |
| Jason E. Kelley | Event Organizer |
| Candice Patton | Young Woman
(as Candice K. Patton) |
| Paul Diaz | Young Man |
| Adémola | NYPD Officer
(uncredited) |
| Eric Shackelford | Lower Eastsider
(uncredited) |
| Stefanie Wood | Runway Model
(uncredited) |
| Sergei Zelinsky | Make Up Artist
(uncredited) |