| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Ruben Santiago-Hudson | Captain Roy Montgomery |
| Molly C. Quinn | Alexis Castle
(as Molly Quinn) |
| Jon Huertas | Javier Esposito |
| Tamala Jones | Lanie Parish |
| Seamus Dever | Kevin Ryan |
| Diana Maria Riva | Det. Roselyn Karpowski |
| Arye Gross | M.E. Sidney Perlmutter |
| Brennan Elliott | Jason Cosway |
| Matt Winston | Evan Hinkle |
| Gareth Williams | Wesley Grovner |
| Amy Stewart | Brandy Rossi |
| Jim O'Heir | Hal Rossi |
| Linara Washington | Christina Marx |
| Marco Martinez | Eric Marx |
| Dinora Walcott | Det. Mindy Stegner |
| Brian Atkinson | Messianic-Looking Guy
(as Brian Allen) |
| Vanessa Motta | Housewife #1
(uncredited) |
| Martin Pierron | Full Moon Crow Freak
(uncredited) |
| Monica Staggs | Housewife #2
(uncredited) |