| Emily Deschanel | Temperance Brennan |
| David Boreanaz | Seeley Booth |
| Michaela Conlin | Angela Montenegro |
| Eric Millegan | Zack Addy |
| Tamara Taylor | Camille Saroyan |
| T.J. Thyne | Jack Hodgins |
| Ryan O'Neal | Father Toby Coulter |
| Loren Dean | Russ Brennan |
| Patricia Belcher | Caroline Julian |
| Ryan Cutrona | FBI Deputy Director Robert Kirby |
| Barbara Williams | Barbara Harper |
| Madison Mason | Judge Ted Kemper |
| Lou Beatty Jr. | Marvin Beckett |
| Bryan Cuprill | Asst. U.S. Attorney Dan Burridge |
| Kathy Reichs | Professor Constance Wright |
| Joseph Ruskin | Professor William Grayson |
| Joe Davis | Security Guard |