| Reese Witherspoon | Madeline Martha Mackenzie |
| Nicole Kidman | Celeste Wright |
| Shailene Woodley | Jane Chapman |
| Laura Dern | Renata Klein |
| Zoë Kravitz | Bonnie Carlson |
| Adam Scott | Ed Mackenzie |
| James Tupper | Nathan Carlson |
| Jeffrey Nordling | Gordon Klein |
| Kathryn Newton | Abigail Carlson |
| Iain Armitage | Ziggy Chapman |
| Alexander Skarsgård | Perry Wright |
| Meryl Streep | Mary Louise Wright |
| Darby Camp | Chloe Mackenzie |
| Cameron Crovetti | Josh Wright |
| Nicholas Crovetti | Max Wright |
| Martin Donovan | Martin Howard |
| Merrin Dungey | Detective Adrienne Quinlan |
| Crystal Fox | Elizabeth Howard |
| Ivy George | Amabella Klein |
| Mo McRae | Michael Perkins |
| Douglas Smith | Corey Brockfield |
| Robin Weigert | Dr. Amanda Reisman |
| Michael Andrew Baker | Defense Attorney Steve Gartner |
| Linda Burzynski | CHP Officer Lydia Seabrook |
| Maryfrances Careccia | Agent Sparks |
| Howard Chan | CHP Officer Joel Maron |
| Chloe Coleman | Skye Carlson |
| Elizabeth Liang | Federal Courtroom Deputy |
| Charles Maceo | Agent Nelson |
| Duvier Poviones | Daniel |
| Jeryl Prescott | Cecilia |
| Scott Alan Smith | Federal Prosecutor James Taylor |
| Sunday Rose Kidman-Urban | School Child |
| Faith Margaret Kidman-Urban | School Child |
| Leonard Kelly-Young | Judge Vincent Pagano |
| Khalilah Joi | Young Elizabeth |
| Laura Linda Bradley | Blake |
| Anthony Molinari | FBI Agent |