| Dwayne Johnson | Spencer Strasmore |
| John David Washington | Ricky Jerret |
| Omar Benson Miller | Charles Greane |
| Donovan W. Carter | Vernon Littlefield |
| Troy Garity | Jason Antolotti |
| London Brown | Reggie |
| Jazmyn Simon | Julie Greane |
| Rob Corddry | Joe Krutel |
| Dulé Hill | Larry Siefert |
| Arielle Kebbel | Tracy Legette |
| Anabelle Acosta | Annabella |
| Patrick St. Esprit | Hal, Dallas Cowboys GM |
| Carlease Burke | Mama Littlefield |
| Tyler James Williams | Waterboy |
| Antoine Harris | Alonzo |
| Phoebe Dorin | Mrs. Lowenstein |
| Hakim Callender | Marcus |
| Jessica Bialick | Hostess |
| Marc Simpson | Eugene |
| Brett Weiss | 'Stick' Kid |
| Kevin Moody | 'Test Drive' Kid |
| Jorge Moreno | Band Singer |
| Michael Orozco | Valet |
| Ellen Marguerite Cullivan | Biltmore Lobby |
| Patrick H. Fox | Hotel Guest |
| Joseph Giambrone | Hotel Guest |
| Tracy Lee | NFL Player |
| Josue Louis-Charles | Party Guest |
| Curtis Lyons | Football Player |
| Danny Machado | Valet Attendant |
| Melanie Marie | Hotel Guest with Spencer |
| Plus Pierre | Marlins Fan |
| George Schoendorfer | Coach |
| Darwin King Tademy Jr. | Office Staff |
| Kirk Urquhart | Anderson Financial Consultant |
| Joe Vida | Spencers Newly Hired Employee |
| Gowon Walker | Vernon's Uncle |
| Jevon White | Assistant Coach |
| Zac Yorke | Miami Dolphin's NFL Player |