| Joel Kinnaman | Takeshi Kovacs |
| James Purefoy | Laurens Bancroft |
| Martha Higareda | Kristin Ortega |
| Chris Conner | Poe |
| Dichen Lachman | Reileen Kawahara |
| Ato Essandoh | Vernon Elliot |
| Kristin Lehman | Miriam Bancroft |
| Trieu Tran | Mr. Leung |
| Renée Elise Goldsberry | Quellcrist Falconer |
| Byron Mann | O.G. Kovacs |
| Waleed Zuaiter | Samir Abboud |
| Antonio Marziale | Isaac Bancroft |
| Olga Fonda | Sarah |
| Daniel Bernhardt | Jaeger |
| Paul Lazenby | Trooper #1 |
| Jane Hancock | Orientation Woman |
| John Emmet Tracy | Warden Sullivan |
| Tahmoh Penikett | Dimitri Kadmin |
| Troy Rudolph | Re-Meet Dad |
| Elfina Luk | Re-Meet Mom |
| Glynis Davies | Old Junkie Woman |
| Howie Lai | Meditech 1 |
| Kwasi Thomas | Meditech 2 |
| Joel Montgrand | Meditech 3 |
| Nicole Anthony | Trainee |
| Zahf Paroo | Curtis |
| Shayn Walker | Security Guard |
| Cory Chetyrbok | Spirit Saver Demonstrator |
| Jay Cardinal Villeneuve | Spirit Saver Demonstrator 2 |
| Morgan Gao | Young Tak |
| Riley Lai Nelet | Young Reileen |
| Dario de Iaco | Gene Freak Neanderthal |
| Fraser Aitcheson | Gene Freak Rhino Man |
| Amitai Marmorstein | Junkie Dealer |
| Simon Chin | Alcatraz Guard |
| Alyson Bath | Woman Speaking Hologram |
| Lisa Chandler | Mary Lou Henchy |
| Leonie Bennett | Sexy Synth Girl |
| Kat Pasion | 'B' Side Synth |
| Jason McKinnon | Handsome Guy |
| Tina Grant | Overextended Mom |
| Richard Ian Cox | Cheap Lawyer |
| Nickolas Baric | Kadmin's Man 1 |
| Nigel Brighton | Man in Black |
| Peter Brown | Attendant |
| Jim Eliason | Police Officer (with Mohawk) |
| Matt Frewer | Carnage |
| Sean Kohnke | Kadmin's Man 2 |
| Will Yun Lee | Stronghold Kovacs |
| Sarah Porscheta | Poe Woman |
| Scott Corban Sikma | Bartender |
| Celeste White Steele | Fell Station Detective |
| Linley Subryan | Grounder |