| James Franco | Jake Epping |
| Sarah Gadon | Sadie Dunhill |
| Cherry Jones | Marguerite Oswald |
| George MacKay | Bill Turcotte |
| Daniel Webber | Lee Harvey Oswald |
| T.R. Knight | Johnny Clayton |
| Kevin J. O'Connor | Yellow Card Man |
| Josh Duhamel | Frank Dunning |
| Chris Cooper | Al Templeton |
| Gil Bellows | FBI Agent James B. Hosty |
| Grantham Coleman | Bonnie Ray Williams |
| Wilbur Fitzgerald | Captain Will Fritz |
| Leon Rippy | Harry Dunning |
| Constance Towers | Old Sadie Dunhill |
| Erica Anderson | Sadie's Cousin #1 |
| Gary Biggar | Police Escort #1 |
| Ian Busher | Reporter #3 |
| Deanna Cahill | Jackie Kennedy |
| Alexandra Castillo | Mayor |
| Christopher Dyson | Biggest Plainclothes Cop |
| Ira Einsohn | Abraham Zapruder |
| Russell Ferrier | Agent Shanklin |
| Sharon Forrester | Skinny Woman |
| Mark Alastair | Reporter #2 |
| Marianne Galloway | Woman in Red |
| Carine Gilbert | Girl |
| Howard Goldthwaite | Hobo #1 |
| Jeff Gruen | Police Escort #2 |
| Christian Heep | Man with Black Umbrella |
| M. John Kennedy | Reporter #4 |
| Iain Lacourt | Fellow |
| Brandon Ludwig | Rookie |
| Holly Macintyre | Little Girl |
| Chelsea Norgren | Sadie's Cousin #2 |
| Christopher Phipps | JFK |
| David Price | Hobo #2 |
| Laura Reeves | Babushka Lady |
| John Ross | Dallas Police Officer #1 |
| Jerry Schaefer | Greyhound Clerk |
| Kent Sheridan | Reporter #1 |
| Alison Smiley | Owner |
| Timothy Talbott | Hobo #3 |
| Lorna Wright | Mother |
| Isabella Fowler | School Girl (1966) |
| John 'JR', Ross | Dallas Police Officer Sneddon |
| Joe Atinsky | Houston and Elm Pedestrian |
| TaKenya Banks | Adrienne |
| R. Steven Blake | JFK Secret Service Agent |
| Jason Bremer | Grassy Knoll Photographer |
| Alex Ryan Brown | Assasination Spectator |
| Latrice Butts | Street Crowd |
| Jeff Caperton | Agent Roy Kellerman |
| Corey Chainey | Cowboy |
| Rebecca Chulew | Houston and Elm Pedestrian |
| Alek Cole | Anthony |
| Terrie Cooklin | Dallas Dignitary |
| Clarence Cross | Houston and Elm Pedestrian |
| Ellen Crouch | Houston and Elm Pedestrian |
| Daniel B. Davis | Press Reporter |
| Cyndy Day | Sadie Photodouble |
| Greg Fallon | Reporter |
| Rebecca Gamble | Dallas Couple Under Bridge |
| Candiss Nicole Gandy | Dallas Dignitary |
| Chris Gleason | ND Driver |
| Paul Heckmann | Photographer on Grassy Knoll |
| Allene Hillegas | Pedestrian |
| Shelley Kaehr | Mary Moorman |
| Tommy James Murphy | Jake Photodouble |
| Jenifer Noel | Spectator |
| Dave Reachill | Kennedy Supporter |
| Lisa Finan Rogers | Zapruder's Assistant |
| Kimberly Ryans | Houston and Elm Pedestrian |
| Max Silvestri | Patrick |
| Matt Smith | Inmate 1 |
| Brooklyn Sudano | Christy Epping |
| R.J. Taylor | Police officer |
| Matthew Thornton | Bill Newman |
| Anna Vocino | Jackie Kennedy |
| Rorie Vogel | Kennedy Speech Attendee |