| Mahershala Ali | Wayne Hays |
| Carmen Ejogo | Amelia Reardon |
| Stephen Dorff | Roland West |
| Scoot McNairy | Tom Purcell |
| Ray Fisher | Henry Hays |
| Brett Cullen | Gerald Kindt |
| Sarah Gadon | Elisa Montgomery |
| Michael Greyeyes | Brett Woodard |
| Mamie Gummer | Lucy Purcell |
| Rhys Wakefield | Freddy Burns |
| Jodi Balfour | Lori |
| Seth Barrish | Priest |
| Candyce Hinkle | Patty Faber |
| Joseph Curtis Callender | Liquor Store Proprietor
(as Joseph Callender) |
| John Earl Jelks | Sam Whitehead |
| Lorenzo Yearby | Neighbor #1 |
| David T. Anthony | |
| Sasha Morfaw | Neighbor #3 |
| James MacDonald | Major Blevins |
| Greg Bryan | Jay Bunda |
| L. Warren Young | Detective |
| Bill Kelly | Detective Hobbs |
| David Stanbra | Detective Segar |
| Myk Watford | Detective Morelli |
| Michael Broderick | Special Agent John Bowen |
| Tim Griffin | Special Agent Burt Diller |
| Brian Oerly | Eddie |
| Isaiah C. Morgan | Young Henry Hays |
| Kennedi Butler | Young Becca Hays
(as Kennedi Lynn Butler) |
| Bojesse Christopher | Detective Richard Kitting |
| Bea Santos | 21 Year Old Julie Purcell |
| Chad Cline | Sallisaw PD Officer |
| Brooklyn Courtney-Moore | Soda Can Girl #1 |
| Berkeley Courtney-Moore | Soda Can Girl #2 |
| Mary Kathryn Bryant | State Police Receptionist |
| Jon Walters | |
| James Anderson | Arkansas State Police Detective
(uncredited) |
| Michael Graziadei | Dan O'Brien
(uncredited) |
| Vu Ha | Viet Cong Soldier
(uncredited) |
| James Michael Smith | State Trooper
(uncredited) |