| Dominic West | Off. James 'Jimmy' McNulty |
| John Doman | Dep. Comm. for Operations William A. Rawls |
| Frankie Faison | Commissioner Ervin H. Burrell |
| Aidan Gillen | Councilman Thomas 'Tommy' Carcetti |
| Deirdre Lovejoy | Asst. State's Atty. Rhonda Pearlman |
| Clarke Peters | Det. Lester Freamon |
| Wendell Pierce | Det. William 'Bunk' Moreland |
| Lance Reddick | Maj. Cedric Daniels |
| Andre Royo | Reginald 'Bubbles' Cousins |
| Sonja Sohn | Det. Shakima 'Kima' Greggs |
| Jim True-Frost | Roland 'Prez' Pryzbylewski |
| Robert Wisdom | Howard 'Bunny' Colvin |
| Seth Gilliam | Sgt. Ellis Carver |
| Domenick Lombardozzi | Sgt. Thomas 'Herc' Hauk |
| Reg E. Cathey | Norman Wilson |
| Chad L. Coleman | Dennis 'Cutty' Wise |
| Jamie Hector | Marlo Stanfield |
| Glynn Turman | Mayor Clarence V. Royce |
| J.D. Williams | Preston 'Bodie' Broadus |
| Michael Kenneth Williams | Omar Little |
| Corey Parker Robinson | Det. Leander Sydnor |
| Jermaine Crawford | Duquan 'Dukie' Weems |
| Maestro Harrell | Randy Wagstaff |
| Julito McCullum | Namond Brice |
| Tristan Mack Wilds | Michael Lee |
| Gbenga Akinnagbe | Chris Partlow |
| Robert F. Chew | Joseph 'Proposition Joe' Stewart |
| Anwan Glover | Slim Charles |
| Hassan Johnson | Roland 'Wee-Bey' Brice |
| Dan De Luca | David Parenti |
| Susan Duvall | Assistant Principal Marcia Donnelly |
| Dravon James | Grace Sampson |
| Christopher Mann | Councilman Anthony 'Tony' Gray |
| Cleo Reginald Pizana | Chief of Staff Coleman Parker |
| Frederick Strother | State Delegate Odell Watkins |
| Boris McGiver | Lt. Charles Marimow |
| Edward T. Norris | Det. Edward Norris |
| Delaney Williams | Sgt. Jay Landsman |
| Sandi McCree | De'Londa Brice |
| Alfonso Christian Lover | Old Face Andre |
| Felicia Pearson | Felicia 'Snoop' Pearson |
| Al Brown | Maj. Stanislaus Valchek |
| Brandy Burre | Theresa D'Agostino |
| Tyreeka Freamon | Middle School Clerk |
| Brian Anthony Wilson | Det. Vernon Holley |
| Armando Cadogan Jr. | Bubbles' Tormentor |
| Nathan Corbett | Donut |
| Thuliso Dingwall | Kenard |
| Taylor King | Zenobia Dawson |
| Rashad Orange | Sherrod |
| Michael Ahl | Detective |
| Benjamin Busch | Off. Anthony Colicchio |
| Richard Hidlebird | Principal Claudell Withers |
| Destiny Jackson-Evans | Crystal Judkins |
| Dana Jay | Gangmember (Omars Crew) Camera Man |
| Jeffrey Lorenzo | Karim Williams |
| David L. Marston | Newspaper Photographer |
| Isis McCray | Tiff |
| Rakiya Orange | Charlene Young |
| Rick Otto | Off. Kenneth Dozerman |
| Kwame Patterson | 'Monk' Metcalf |
| Lenecia Renée Porro | News Journalist |
| Ryan Sands | Off. Lloyd 'Truck' Garrick |
| David J. Smolar | Newspaper Reporter |
| Jason Wharton | Albert Stokes |
| Gregory L. Williams | Det. Michael Crutchfield |