| Alan Alda | Senator Arnold Vinick |
| Kristin Chenoweth | Annabeth Schott |
| Allison Janney | C.J. Cregg |
| Joshua Malina | Will Bailey |
| Mary McCormack | Kate Harper |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Jimmy Smits | Matthew Santos |
| Martin Sheen | President Josiah Bartlet |
| Janeane Garofalo | Louise Thornton |
| Teri Polo | Helen Santos |
| Nina Siemaszko | Ellie Bartlet |
| Ben Weber | Vic Faison - Ellie's Fiancé |
| Cress Williams | Lester |
| Ron Canada | Under Secretary of State Theodore Barrow |
| NiCole Robinson | Margaret Hooper |
| Matthew Del Negro | Bram Howard |
| Karis Campbell | Ronna |
| Diana Maria Riva | Edie Ortega |
| Shelley Robertson | Brenda Burke - Ronnie Burke's Mother |
| Lou Beatty Jr. | Wilson Burke - Ronnie Burke's Uncle |
| John Littlefield | Agent |
| Duane R. Shepard Sr. | Pastor |