| Stockard Channing | Abbey Bartlet
(credit only) |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Joshua Malina | Will Bailey |
| Mary McCormack | Kate Harper |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Martin Sheen | President Josiah Bartlet |
| Alan Alda | Senator Arnold Vinick |
| Kristin Chenoweth | Annabeth Schott |
| Gary Cole | Vice President Bob Russell |
| Ed O'Neill | Governor Eric Baker D-PA |
| Penn Jillette | Penn Jilette
(as Penn & Teller) |
| Teller | Teller
(as Penn & Teller) |
| Elisabeth Moss | Zoey Bartlet |
| Mary Kay Place | Surgeon General Millicent Griffith |
| Ron Canada | Under Secretary of State Theodore Barrow |
| Stanley Kamel | Stanley |
| NiCole Robinson | Margaret Hooper |
| Renée Estevez | Nancy |
| Timothy Davis-Reed | Mark O'Donnell |
| Kris Murphy | Katie Witt |
| Ben Murray | Curtis Carruthers |
| Paul Rae | Walter |
| Steve Kramer | Deputy Secretary |
| Tracey Costello | Agent Moody |
| Elizabeth Karr | Reporter #4 |
| James Sharpe | Reporter |
| Brian Ceponis | Secret Service Agent
(uncredited) |
| Ken Weiner | Dr. Stremlowe
(uncredited) |