| Steven Strait | Jim Holden |
| Cas Anvar | Alex Kamal |
| Dominique Tipper | Naomi Nagata |
| Wes Chatham | Amos Burton |
| Frankie Adams | Roberta 'Bobbie' W. Draper |
| Florence Faivre | Julie Mao |
| Shawn Doyle | Sadavir Errinwright |
| Shohreh Aghdashloo | Chrisjen Avasarala |
| Chad L. Coleman | Col. Frederick Lucius Johnson |
| Terry Chen | Dr. Praxidike 'Prax' Meng |
| Cara Gee | Camina Drummer |
| Jared Harris | Anderson Dawes |
| Alden Adair | Staz |
| Andrew Rotilio | Diogo |
| Dylan Brentwood | Black Sky OPA Leader |
| Grace Lynn Kung | Doris |
| Kevin Claydon | Edin |
| Leah Madison Jung | Mei |
| Tannis Burnett | Station Doctor |
| Ted Atherton | Dr. Strickland |
| Tim Post | Surly Belter Crewman |
| Mark Quigley | Tyhco Dock Worker |