| Jared Padalecki | Sam Winchester |
| Jensen Ackles | Dean Winchester |
| Misha Collins | Castiel |
| Mark Sheppard | Crowley
(as Mark A. Sheppard) |
| Erica Carroll | Hannah /
Caroline Johnson |
| Travis Aaron Wade | Cole Trenton |
| Ruth Connell | Rowena MacLeod |
| Michael Antonakos | Raul |
| Chelsea Hobbs | Catlin |
| Kirsten Comerford | Elle |
| Elysia Rotaru | Shaylene Johnson |
| Steve Belford | Joe Johnson |
| Viv Leacock | Gerald |
| Jackson Berlin | Male Demon #1 |
| Alyson Bath | Tiana |
| Wesley Salter | Male Demon #2 |
| Jaeson Lee | Handler |
| Emma Day | Female Demon |
| Guy Fauchon | Marty |
| Josh Ssettuba | Busboy |
| Matthew Enright | Guy in Alleyway
(uncredited) |