| Winona Ryder | Joyce Byers |
| David Harbour | Jim Hopper |
| Millie Bobby Brown | Eleven |
| Finn Wolfhard | Mike Wheeler |
| Gaten Matarazzo | Dustin Henderson |
| Caleb McLaughlin | Lucas Sinclair |
| Noah Schnapp | Will Byers |
| Sadie Sink | Max Mayfield |
| Natalia Dyer | Nancy Wheeler |
| Charlie Heaton | Jonathan Byers |
| Joe Keery | Steve Harrington |
| Maya Hawke | Robin Buckley |
| Brett Gelman | Murray Bauman |
| Priah Ferguson | Erica Sinclair |
| Matthew Modine | Martin Brenner |
| Paul Reiser | Sam Owens |
| Jamie Campbell Bower | Friendly Orderly |
| Logan Riley Bruner | Fred Benson |
| Cara Buono | Karen Wheeler |
| Joe Chrest | Ted Wheeler |
| Catherine Curtin | Claudia Henderson |
| Mason Dye | Jason Carver |
| Eduardo Franco | Argyle |
| Amybeth McNulty | Vickie |
| Elodie Grace Orkin | Angela |
| Gabriella Pizzolo | Suzie |
| Joseph Quinn | Eddie Munson |
| Jessica Arden Napier | Five |
| Grace Van Dien | Chrissy Cunningham |
| Martie Marie Blair | Young Eleven |
| Christian Ganiere | Ten |
| Tristan Spohn | Two |
| Chloe Adona | Nine |
| Logan Allen | Jake |
| Nicholas Azarian | Kid in Goggles |
| Hayley Baron | Friendly Girl #2 |
| Elizabeth Becka | Dr. Ellis |
| Trey Best | Jeff |
| Regina Ting Chen | Ms. Kelly |
| Todd d'Amour | Coach |
| Anna Grace Davidson | Drama Kid |
| Elise Falanga | Lenora Neighbor |
| Jeremiah Friedlander | Fourteen |
| Morgan Gao | Three |
| David Gibson | Friendly Mailman |
| Sophie Elizabeth Gonzalez | Art Kid |
| Grant Goodman | Freak |
| Ethan J Green | Sixteen |
| Oliver J Green | Seventeen |
| Jayden Griffin | Freshman Teammate |
| Scout Hamrick | Candance |
| Clayton Johnson | Andy |
| David Alexander Kaplan | Twelve |
| Haroon Khan | Chess Kid |
| Gregory Konow | Announcer |
| Gwydion Lashlee-Walton | Gareth |
| Shane Donovan Lewis | Math Kid |
| Lucinda Marker | Math Teacher |
| Jennifer Marshall | Susan Hargrove |
| Sparrow Nicole | Four |
| Laura Niemi | Mrs. Gracey |
| Tristan Peters | Chess Kid #2 |
| Shawnee Pourier | Cute Girl |
| Tinsley Price | Holly Wheeler |
| Julia Reilly | Tammy Thompson |
| Hunter Romanillos | Teammate |
| Candice Rose | Chrissy's Mom |
| Sam Salary | Stern Orderly |
| Maximo Salas | Wrestler Teen |
| Olivia Sembra | Eighteen |
| Brook Sill | Brenda |
| Christopher Strand | Chrissy's Dad |
| Gabriella Surodjawan | Mean Girl |
| Abby Townsend | Friendly Girl |
| Lana Jean Turner | Seven |
| Alex Wagenman | Mean Boy |
| De'Jon Watts | Six |
| Bentley Williams | Fifteen |
| Hendrix Yancey | Thirteen |
| Joseph Ortega | Lenora Hills Laughing Kid |
| Chad Paetznick | Schoolbus Driver, Teacher |
| Sage Shirley | High School Student |
| Nick Benas | Soldier |
| Arthur Bening | Chuck (Kissing Basketball Player) |
| Alexander Eadie | Student Spectator |
| Brooklyn Paige Flamm | Hawkins High Student |
| Alex D. Jennings | Jock |
| Chase Ledgerwood | Soldier |
| Mark Murtha | Hungover Hawkins Kid |
| Babatunde Oyewo | Town People |
| Robert Tinsley | Rambo |
| Myles Truitt | Patrick |
| Wyatt Werneth | Sullivan Solider |
| Everett Williams | Basket Ball Game Attendee |
| Dawn Young-McDaniel | Friendly Nurse |