| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Ryan Hurst | Harry 'Opie' Winston |
| Johnny Lewis | Kip 'Half Sack' Epps |
| William Lucking | Piermont 'Piney' Winston |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Ally Walker | Agent June Stahl |
| Tory Kittles | Laroy Wayne |
| Dayton Callie | Chief Wayne Unser |
| Jamie McShane | Cameron Hayes |
| Callard Harris | Edmond Hayes |
| Winter Ave Zoli | Lyla Dvorak |
| Titus Welliver | James 'Jimmy' O'Phelan |
| Marcos A. Ferraez | Agent Estevez
(as Marcos De La Cruz) |
| Bellina Logan | Fiona Larkin |
| McNally Sagal | Margaret Murphy |
| Noah Watts | Ferdinand |
| David Labrava | Happy |
| Lela Jane Cortines | Ellie Winston
(as Lela Cortines) |
| John Abendroth | Kenny Winston |
| Nicholas Guest | The Voice of John Teller
(voice) (as Nick Guest) |
| E.R. Ruiz | Gill
(as E.R) |
| Geraldine Keams | Native American Woman |
| Joseph Runningfox | Elder Indian Man |
| Kevin P. Kearns | Luke
(as Kevin Kearns) |
| Mylo Ironbear | Native Ammo Maker
(uncredited) |