| Charlie Hunnam | Jackson 'Jax' Teller |
| Katey Sagal | Gemma Teller Morrow |
| Mark Boone Junior | Robert 'Bobby Elvis' Munson |
| Kim Coates | Alexander 'Tig' Trager |
| Tommy Flanagan | Filip 'Chibs' Telford |
| Johnny Lewis | Kip 'Half Sack' Epps |
| Maggie Siff | Dr. Tara Knowles |
| Ron Perlman | Clarence 'Clay' Morrow |
| Drea de Matteo | Wendy Case |
| Ryan Hurst | Harry 'Opie' Winston |
| Theo Rossi | Juan Carlos 'Juice' Ortiz |
| William Lucking | Piermont 'Piney' Winston |
| Sprague Grayden | Donna Winston |
| Dendrie Taylor | Luann Delaney |
| Mitch Pileggi | Ernest Darby |
| Glenn Plummer | Sheriff Vic Trammel |
| Emilio Rivera | Marcus Alvarez |
| Tory Kittles | Laroy Wayne |
| David Labrava | Happy |
| Nicholas Guest | The Voice of John Teller
(voice) (as Nick Guest) |
| Michael Potter | Simon |
| Stevie Long | Long John |
| Jon Jon Briones | Asian Elvis |
| Cameron Goodman | Louise Hoffman |
| James Geralden | Male Back-Up Singer |
| Wandah Kay | Female Back-Up Singer |
| Thomas Adisi | Young Jackson Teller
(uncredited) |
| Salina Marie Carter | Female Student #1
(uncredited) |
| Patrick Clement | Poolhall Skinhead
(uncredited) |
| Johnny Drocco | Dude seated at bar
(uncredited) |
| Jaxodus | Nurse
(uncredited) |
| Alan Mueting | Hospital Visitor
(uncredited) |
| Tony Sagastizado I | Mechanic
(uncredited) |
| Dian Van Patten | Star
(uncredited) |
| Jeff Vican | Bar Room Brawler
(uncredited) |