| Patrick Stewart | Capt. Jean-Luc Picard |
| Jonathan Frakes | Cmdr. William Riker |
| LeVar Burton | Lt. Cmdr. Geordi La Forge |
| Michael Dorn | Lt. Worf |
| Gates McFadden | Dr. Beverly Crusher |
| Marina Sirtis | Counselor Deanna Troi |
| Brent Spiner | Lt. Cmdr. Data |
| Jerry Hardin | Samuel Clemens |
| Pamela Kosh | Mrs. Carmichael |
| William Boyett | Policeman |
| Michael Aron | Jack London |
| James Gleason | Dr. Appollinaire |
| Mary Stein | Alien Nurse |
| Alexander Enberg | Young Reporter |
| Whoopi Goldberg | Guinan |
| Bill Cho Lee | Male Patient |
| Majel Barrett | Enterprise Computer
(voice) |
| Teda Bracci | Corpse
(uncredited) |
| Tracee Cocco | Ensign Jae
(uncredited) |
| John Copage | Science Division Officer
(uncredited) |
| Debbie David | Ensign Russell
(uncredited) |
| Van Epperson | Morgue Attendant
(uncredited) |
| Keith Gearhart | Science Division Officer
(uncredited) |
| Malachy Fergus Godfrey | 19th Century San Francisco Citizen
(uncredited) |
| Bob Harks | Priest
(uncredited) |
| Christi Haydon | Starfleet Ensign
(uncredited) |
| Gary Hunter | Sciences Officer
(uncredited) |
| Arvo Katajisto | Devidian Man
(uncredited) |
| Jack Murdock | Begger
(archive footage) (uncredited) |
| Keith Rayve | Command Division Ensign
(uncredited) |
| Robert Seeley | Alien
(uncredited) |
| Guy Vardaman | Darien Wallace
(uncredited) |