| Charlie Cox | Matt Murdock |
| Deborah Ann Woll | Karen Page |
| Elden Henson | Foggy Nelson |
| Jon Bernthal | Frank Castle |
| Elodie Yung | Elektra Natchios |
| Stephen Rider | Blake Tower |
| Rosario Dawson | Claire Temple |
| Scott Glenn | Stick |
| Royce Johnson | Brett Mahoney |
| Wai Ching Ho | Madame Gao |
| Amy Rutberg | Marci Stahl |
| Marilyn Torres | Louisa Delgado |
| Suzanne H. Smart | Shirley Benson |
| Peter Shinkoda | Nobu |
| Ron Nakahara | Hirochi |
| John Pirkis | Stan Gibson |
| Lucas Elliot Eberl | Daniel Gibson |
| Ben Thompson | Quinn |
| John Leonard Thompson | Administrator |
| Michael Nostrand | Hospital Employee |
| Samuel Smith | Officer Reed |
| Mike Keller | Officer Powell |
| Aidan Redmond | Bearded Man |
| Vince Benvenuto | Drug Goon |
| Robert 'Toshi' Kar Yuen Chan | Gangster |
| Nicholas Tucci | Lead Dealer Gosnell |
| Victoria Castle | Susanna |
| Kelsey Wang | Young Woman |
| Allison Winn | Caged Woman |
| Doug Plaut | Infected #1 |
| Massiel Mordan | Infected #2 |
| Shari Abdul | Infected #3 |
| Michael Kenneth Casey | Chaney |
| Adam Hart | Speed |
| Hank Meleski Jr. | Dogs of hell biker |
| Faith Logan | Hospital Patient |