| Naveen Andrews | Sayid Jarrah |
| Nestor Carbonell | Richard Alpert
(credit only) |
| Henry Ian Cusick | Desmond Hume
(credit only) |
| Emilie de Ravin | Claire Littleton |
| Michael Emerson | Ben Linus
(credit only) |
| Jeff Fahey | Frank Lapidus
(credit only) |
| Matthew Fox | Dr. Jack Shephard
(credit only) |
| Jorge Garcia | Hugo 'Hurley' Reyes
(credit only) |
| Josh Holloway | James 'Sawyer' Ford |
| Daniel Dae Kim | Jin-Soo Kwon |
| Yunjin Kim | Sun-Hwa Kwon
(credit only) |
| Ken Leung | Miles Straume |
| Evangeline Lilly | Kate Austen |
| Terry O'Quinn | Man in Black |
| Zuleikha Robinson | Ilana Verdansky
(credit only) |
| Alan Dale | Charles Widmore |
| Neil Hopkins | Liam Pace |
| Kimberley Joseph | Cindy Chandler |
| Sheila Kelley | Zoe |
| Rebecca Mader | Dr. Charlotte Lewis |
| Jodi Lyn O'Keefe | Ava |
| Allan Cole | Sergeant
(as Allen Cole) |
| Mickey Graue | Zack |
| Kiersten Havelock | Emma |
| Christopher Johnson | Police Officer |
| Frederick Koehler | Seamus
(as Fred Koehler) |
| Keegan Boos | Young Sawyer
(archive footage) (uncredited) |
| Melissa Gilbert | Laura Ingalls
(archive footage) (uncredited) |
| James Koons | Widmore Scientist
(uncredited) |
| Michael Landon | Charles Ingalls
(archive footage) (uncredited) |