| Timothy Olyphant | Seth Bullock |
| Ian McShane | Al Swearengen |
| Molly Parker | Alma Garret |
| Jim Beaver | Whitney Ellsworth |
| Brad Dourif | Doc Cochran |
| John Hawkes | Sol Star |
| Paula Malcomson | Trixie |
| Leon Rippy | Tom Nuttall |
| William Sanderson | E.B. Farnum |
| Robin Weigert | Calamity Jane |
| W. Earl Brown | Dan Dority |
| Dayton Callie | Charlie Utter |
| Keith Carradine | Wild Bill Hickock |
| Jeffrey Jones | A.W. Merrick |
| Timothy Omundson | Brom Garret |
| Garret Dillahunt | Jack McCall |
| Ray McKinnon | Reverend H.W. Smith
(as Raymond McKinnon) |
| Sean Bridgers | Johnny Burns |
| Geri Jewell | Jewel |
| Keone Young | Mr. Wu |
| Jamie McShane | Ned Mason |
| Dan Hildebrand | Tim Driscoll |
| Mike Hagerty | Loud Wagoneer
(as Michael Hagerty) |
| Christopher Darga | Byron Sampson |
| James Parks | Clell Watson |
| Ursula Brooks | Whore #6 |
| David Carpenter | Vigilante |
| Misti Cassar | |
| Allison Gammon | |
| Gill Gayle | Huckster |
| Dylan Haggerty | Abusive John |
| Michelle Haner | |
| G.T. Holme | Miner in the Gem Saloon |
| Robyn Hyden | |
| Peter Jason | Con Stapleton |
| Honey Lauren | |
| Victor McCay | |
| Dean Rader-Duval | Jimmy Irons |
| Vanessa Robertson | Whore #4 |
| Raynor Scheine | Prospector #2 |
| Tom Simmons | Poker Player - at No. 10 |
| Everette Wallin | Joey |
| Candice T. Cain | Gem Whore
(uncredited) |
| Julius Callahan | Prospector
(uncredited) |
| Al Collado | Store Proprietor
(uncredited) |
| Jane Leigh Connelly | (uncredited) |
| Michael Keyes | Gun Store Owner
(uncredited) |
| Ashleigh Kizer | Dolly
(uncredited) |
| Gary Leffew | Vigilante
(uncredited) |
| Andy Moore | Dental Patient /
Scam Artist
(uncredited) |
| Bree Seanna Wall | Sofia Metz
(uncredited) |