| Jessica Alba | Max Guevera |
| Michael Weatherly | Logan Cale |
| Alimi Ballard | Herbal Thought |
| Richard Gunn | Calvin 'Sketchy' Theodore |
| J.C. MacKenzie | Reagan 'Normal' Ronald |
| Valarie Rae Miller | Cynthia 'Original Cindy' McEachin |
| John Savage | Donald Lydecker |
| Jensen Ackles | Ben |
| Peter Bryant | Bling |
| Robert Floyd | Father Destry |
| Nana Visitor | Dr. Elizabeth Renfro |
| Fulvio Cecere | Sandoval |
| James Kirk | Young Ben |
| Geneva Locke | Young Max |
| Jenn Forgie | Clerk at Coroner's Office |
| Darren Moore | Nomlie in Cell |
| Chris Lazar | Young Zack |
| Rekha Sharma | Dr. Beverly Shankar |
| Glen Gould | Prisoner |
| Dylan Pearson | Young Jack |
| James R. Bayliss | Manticore Janitor |
| Justin Sain | Pond Man |
| Judith McDowell | Lady With Rosary |
| Colin Lawrence | TAC Sgt. O'Neill |