| Joe Mantegna | David Rossi |
| Shemar Moore | Derek Morgan |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Jeanne Tripplehorn | Alex Blake |
| Thomas Gibson | Aaron Hotchner |
| Josh Stamberg | Mike Acklin |
| Danielle Bisutti | Debra Acklin |
| John Fleck | Arthur Rykov |
| Gary Grubbs | Detective Oren Carr |
| Shelby Young | Mackenzie Acklin |
| Bellamy Young | Beth Clemmons |
| Brad Light | Ross Acklin
(as Brad C. Light) |
| Cade Owens | Jack Hotchner |
| Ian Bieda | Braden Acklin |
| Bobby Hall | E.J. Torres |
| Mary Kathleen Gordon | Dr. Kay Armbruster
(as Mary-Kathleen Gordon) |
| Tony Forsmark | Stone |
| Adam Conger | Judd |
| Willie James Warren Jr. | Randy Harper |
| Hans Obma | Nathan Eades |
| Jeanne Joe | Mrs. Kin Nishio |
| Jon Gale | Bill Pittman |
| Alexandra Bayless | Vanessa Hall
(as Ali Bayless) |
| Nick Saso | Young Arthur Rykov |
| Julee Vadnais | The Teacher
(uncredited) |