| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Jon Huertas | Javier Esposito |
| Seamus Dever | Kevin Ryan |
| Tamala Jones | Lanie Parish |
| Molly C. Quinn | Alexis Castle
(as Molly Quinn) (credit only) |
| Penny Johnson Jerald | Captain Victoria Gates |
| Allan Louis | Captain Frank Mahoney |
| Adam Rose | Mike Boyer |
| Andy Goldenberg | Diego Jiminez |
| Stefan Marks | Archibald Fosse |
| Jerry Ying | Tech |
| Jonathan Adams | Vulcan Simmons
(archive footage) (uncredited) |
| Brian Avers | Harrison Tisdale
(archive footage) (uncredited) |
| Adam Baldwin | Det. Ethan Slaughter
(archive footage) (uncredited) |
| Bryan Biermann | Paramedic
(uncredited) |
| Jack Coleman | Senator William H. Bracken
(archive footage) (uncredited) |
| Jay R. Ferguson | Dick Coonan
(archive footage) (uncredited) |
| Bryan Friday | Thug #2
(archive footage) (uncredited) |
| Julie Gonzalo | Madison Queller
(archive footage) (uncredited) |
| Vivian Kerr | Amanda Lowery
(archive footage) (uncredited) |
| Kasey Mahaffy | Lance Newman
(archive footage) (uncredited) |
| Alyssa Milano | Kyra Blaine
(archive footage) (uncredited) |
| Michael Mosley | Jerry Tyson
(archive footage) (uncredited) |
| Scott Paulin | Jim Beckett
(voice) (uncredited) |
| Laura Prepon | Natalie Rhodes
(archive footage) (uncredited) |
| Ruben Santiago-Hudson | Captain Roy Montgomery
(archive footage) (uncredited) |