| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Ruben Santiago-Hudson | Captain Roy Montgomery |
| Molly C. Quinn | Alexis Castle
(as Molly Quinn) |
| Jon Huertas | Javier Esposito |
| Tamala Jones | Lanie Parish |
| Seamus Dever | Kevin Ryan |
| Wilmer Calderon | Marvin 'Oz' Osminkowski |
| Alastair Duncan | Reginald Easley |
| Joe Reegan | Shawn York |
| Clare Carey | Noreen Hixton |
| Ned Bellamy | Logan Meech |
| Brian Michael Jones | Ty Page |
| Gregory Alan Williams | Jim Van-Eps
(as Gregalan Williams) |
| Josh Wingate | Greg Page |
| John Hemphill | Tom Walters |
| J. Salome Martinez | Todd Shipley
(as J. Salomé Martinez Jr.) |
| Rachel Melvin | Nicole Hixton |
| James Bannon | Voice Actor
(uncredited) |
| Chadney Brewer | Homeless Man
(uncredited) |
| Skoti Collins | Jay Hixton
(uncredited) |
| Giovanni V. Giusti | Homeless John
(uncredited) |
| Dontez Hood | Dreadlocks
(uncredited) |
| Keith Middlebrook | Nick
(uncredited) |