| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Ruben Santiago-Hudson | Captain Roy Montgomery
(credit only) |
| Molly C. Quinn | Alexis Castle
(as Molly Quinn) |
| Jon Huertas | Javier Esposito |
| Tamala Jones | Lanie Parish |
| Seamus Dever | Kevin Ryan |
| Bess Armstrong | Paula Casillas |
| Rachel Boston | Penny Marchand |
| Mercedes Mason | Marina Casillas
(as Mercedes Masöhn) |
| Bre Blair | Toni Johnston |
| Rick Ravanello | Steve Adams |
| David Gianopoulos | Albert Moreno |
| Evan Helmuth | Nick Johnston |
| Kieren Hutchison | Cody Donnelly |
| Paige Rowland | Loreen Carter |
| Patricia Tallman | Vivien Marchand
(uncredited) |