| Jason Bateman | Michael Bluth |
| Portia de Rossi | Lindsay Bluth Fünke |
| Will Arnett | Gob Bluth |
| Michael Cera | George-Michael Bluth |
| Alia Shawkat | Maeby Fünke |
| Tony Hale | Buster Bluth |
| David Cross | Tobias Fünke |
| Jeffrey Tambor | George Bluth Sr. |
| Jessica Walter | Lucille Bluth |
| Henry Winkler | Barry Zuckerkorn |
| Mae Whitman | Ann Veal |
| Judy Greer | Kitty Sanchez |
| Jeff Garlin | Mort Meyers |
| Isla Fisher | Rebel Alley |
| Terry Crews | Herbert Love |
| Andy Richter | Rocky Richter |
| Christine Taylor | Sally Sitwell |
| Liza Minnelli | Lucille Austero |
| Eli Vargas | Perfecto Telles |
| Christine Dunford | Lynda the Producer |
| Richard Jin | Paul 'P-Hound' Huan
(as Richard Jin Namkung) |
| Zoe Levin | High School Girl #1 |
| Lauren Patten | High School Girl #2 |
| Keri Russell | Widow Carr
(voice) |
| Jordan Black | Bartender |
| Jay Johnston | Officer Taylor |
| Jerry Minor | Officer Carter |
| Jim Cramer | Jim Cramer |
| Bob Glouberman | Dave the Aide |
| Justin Grant Wade | Steve Holt |
| Woon Young Park | Marauder |
| Adam Cardon | Talent Agent |
| Scott Rosenfeld | Reporter |
| Ron Howard | Narrator
(voice) (uncredited) |
| Tom Massmann | Love Security Guard
(uncredited) |
| Tim Russ | Babies Having Babies Crew
(uncredited) |
| Mallory Yarnall | Ashley Gabriel
(uncredited) |