| David Duchovny | Fox Mulder |
| Gillian Anderson | Dana Scully |
| Mitch Pileggi | Walter Skinner |
| Garry Shandling | Fox Mulder /
Garry Shandling |
| Téa Leoni | Dana Scully /
Tea Leoni
(as Tea Leoni) |
| Harris Yulin | Cardinal O'Fallon |
| Wayne Federman | Wayne Federman |
| Paul Lieber | Micah Hoffman |
| Bill Dow | Chuck Burks |
| Tim Roe | Zombie |
| Barry K. Thomas | Sugar Bear |
| Tina M. Ameduri | Tina |
| Bill Millar | Director |
| Tony Amendola | Cigarette Smoking Pontiff
(uncredited) |
| Chris Carter | Cinema Audience
(uncredited) |
| Minnie Driver | Cinema Audience
(uncredited) |
| André Fortin | Zombie Dancer
(uncredited) |
| David Alan Grier | Cinema Audience
(uncredited) |
| Steve Kiziak | David Duchovny
(uncredited) |